Cart: 0,00€
X Isuu Mastodon
  • Free Shipping for all Order of 36,30€ Spain
Cart: 0,00€

Rheumatological diseases caused by DAO deficiency

The diagnosis of fibromyalgia is not easy, sometimes it takes years to diagnose it. This is because no abnormalities are seen in the physical examination of the person, the doctor cannot assess morning stiffness, extreme pain, chronic fatigue with the naked eye, because they are not quantifiable. But today, there are new biomarkers, such as the activity of the enzyme diamine oxidase (DAO), unfortunately, few doctors are up to date on this subject. To detect the activity of the DAO enzyme, diagnostic methods and new treatments have been developed.

Rheumatological diseases caused by DAO deficiency Rheumatological diseases caused by DAO deficiency

we read it for you

Fibromyalgia, muscle pain, chronic fatigue due to DAO deficiency


DAO deficiency and associated diseases. Fibromyalgia, chronic fatigue and widespread muscle pain


Fibromyalgia is a disease that groups symptoms and musculoskeletal disorders, patients who suffer from them suffer from extreme fatigue, persistent pain, stiff muscles, difficulty sleeping, headaches, memory loss among others, which generally prevent the person's daily routine.

Fibromyalgia symptoms, chronic fatigue and widespread muscle pain

The main symptom that characterizes fibromyalgia is generalized musculoskeletal pain throughout the body and/or muscle stiffness that affects at least three anatomical areas and lasts for more than three months. The pain is generally very intense and on many occasions it is very difficult to describe. It generally worsens with intense physical activity, cold and emotional stress.

Fibromyalgia symptoms occur mostly in the lower back, neck, trapezius, chest, and thighs. Some people have muscle spasms and/or localized contractures.

Other symptoms may include headache, migraine, restless leg syndrome, difficulty concentrating, difficulty remembering or forgetfulness, tinnitus, and lack of motor coordination.

In many patients fibromyalgia also causes sleep disorders, intense weakness, depression, anxiety attacks, digestive problems such as constipation.

Chronic fatigue is always present in all the activities carried out by fibromyalgia patients, which makes performing daily tasks a great difficulty for them. Depending on the severity and the degree variation, this tiredness can range from bearable to a disability that limits tasks both personally and professionally.

Influence of Histamine in fibromyalgia, chronic fatigue and general muscle pain

Currently there is no cure for fibromyalgia, current treatments are to relieve symptoms. Among the treatments we find Fibrodao 60 capsules of Dr Health.

Histamine in the body causes dilation of blood vessels, as well as its accumulation in muscle tissue, and this is what causes pain and chronic fatigue. Histamine mediates many processes such as inflammation, gastric acid secretion, and regulation of immune function.

Histamine is produced by our body, but histamine can also come from abroad, that is, ingested with food (See the article on how Naturdao can help us at the end).

Diamine Oxidase (DAO) Enzyme

The best way to treat fibromyalgia, chronic fatigue, and muscle pain is by inactivating ingested histamine.

The primary function of DAO is to prevent histamine ingested through food from reaching the bloodstream from the intestine. We find Diamino oxidase in the small intestine, kidneys, liver, and leukocytes. Histamine is produced continuously in the body and is excreted via the intestine, and is degraded by DAO when it passes through the intestinal mucosa.

DAO can be inhibited by alcohol, some drugs. But, on the other hand, some people have very low levels of DAO in the blood, this causes the levels of histamine in the blood to be high, which is why certain pathologies are triggered, such as fibromyalgia, muscle pain or chronic fatigue. .

Treatment of fibromyalgia, muscle pain and chronic fatigue with DAO

Diamino oxidase detection is an important biomarker for diagnosing fibromyalgia, chronic fatigue or muscle pain. For this, it is important to carry out a genetic study of the genotypes involved as well as plasma measurement.

Once diagnosed, DAO supplementation breaks down excess histamine, thus preventing the development of fibromyalgia symptoms, chronic fatigue, and widespread muscle pain.

In addition to the contribution of DAO supplements, it is necessary to carry out a diet poor in foods with a high histamine content.

You also have to avoid taking histamine-releasing drugs.

Bibliographic references:

Garcia-Martin et al. Histamine pharmacogenomics. Pharmacogenomics 2009; 10(5):867-883.
Maintz et al. Histamine and histamine intolerance. Am J Clin Nutr 2007; 85:1185-1196.
Jarisch et al. Histamin-intolerance. Histamin and Seekrankheit, 2 edn. Stuttgart, Germany: Georg Thieme Verlag KG, 2004.
Izquierdo-Casas et al. Low serum diamine oxidase (DAO) activity levels in patients with migraine. J Physiol Biochem 2018;74(1):93-99.
Garcia-Martin et al. Diamine oxidase rs10156191 and rs2052129 variants are associated with the risk for migraine. Headache 2015;55(2):276-86.
Agundez et al. The Diamine Oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs. PLOS 2012; 7(11):e47571.
Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd ed. Cephalalgia. 2018; 38:1-211.
Image from
Article extracted from the Linkedin of

related products

Reviews de Rheumatological diseases caused by DAO deficiency

Related Manufacturers / Laboratories

Related Categories

By clicking on 'accept all cookies', you accept that cookies are stored on your device to improve site navigation, analyze its use, and collaborate with our marketing studies.
Cookie Settings
Accept all cookies

Privacy Preference Center

When you visit any website, it may collect or store information on your browser, generally through the use of cookies. This information may be about you, your preferences, or your device, and is used primarily to make the site work as expected. The information generally does not directly identify you, but it can provide you with a more personalized web experience. Because we respect your right to privacy, you can choose not to allow us to use certain cookies. Click on each category heading to learn more and change our default settings. However, blocking some types of cookies may affect your experience on the site and the services we can offer.

[Cookies Policy] [More information]

Allow them all

Manage consent preferences

Strictly necessary cookies Always active

These cookies are necessary for the website to function and cannot be disabled in our systems. They are usually configured to respond to actions you take to receive services, such as adjusting your privacy preferences, logging into the site, or filling out forms. You can set your browser to block or alert the presence of these cookies, but some parts of the website will not work. These cookies do not store any personally identifiable information.

Performance Cookies

These cookies allow us to count visits and traffic sources so that we can measure and improve the performance of our site. They help us to know which pages are the most or least popular, and to see how many people visit the site. All the information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you visited our site, and therefore we will not be able to know when you visited it.

Functionality Cookies

These cookies allow the site to offer better functionality and personalization. They may be set by us or by third parties whose services we have added to our pages. If you do not allow these cookies some of our services will not work properly. It also enables storage related to security, such as authentication functionality, fraud prevention, and other user protection.

Targeted cookies

These cookies may be throughout the website, placed by our advertising partners. These businesses may use them to build a profile of your interests and show you relevant ads on other sites. They do not store personal information directly, but are based on the unique identification of your browser and Internet access device. If you do not allow these cookies, you will have less targeted advertising.

Social network cookies

These cookies are set by a number of social networking services that we have added to the site to allow you to share our content with your friends and networks. They are able to track your browser across other sites and create a profile of your interests. This may modify the content and messages you find on other web pages you visit. If you do not allow these cookies you will not be able to see or use these sharing tools.

Confirm my preferences