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Legumactive ® is a 100% NATURAL method with legumes of organic selection, it offers a powerful enzymatic activity of VEGETABLE DAO (Diamino Oxidase), Catalase (CAT) and Phytonutrients.
The enzyme Catalase (CAT) provides oxygen favoring the balance for the decomposition of the DAO-Histamine reaction . Recent scientific studies made from human intestinal cells indicate that when histamine is degraded by means of DAO, toxic compounds such as Hydrogen Peroxide, Ammonia and Imidazole Acetaldehyde are released from it, however, with the presence of CAT this does not happen
Food supplement based on Legumactive®, which is a 100% natural method with legumes of organic selection, offers a powerful enzymatic activity of DAO (Diamino Oxidase) and Catalase together with its Phytonutrients. Plant Diamine Oxidase (DAO) is the first and only one to hit the market as such, offering 3,000,000 HDU.
Alimentary histaminosis , associated with pseudoallergic phenomena, can occur with the ingestion of histamine-containing foods , such as red wine, beer, chocolate, sauerkraut, fish, and processed meats. Histaminosis is an enteric dysfunction that frequently affects the population of industrialized countries. This disorder is more common in people with low levels of intestinal histaminase, a copper-containing diamine oxidase capable of catalyzing the oxidative breakdown of histamine to produce H2O2, NH3, and imidazole acetaldehyde. Histamine sensitivity is associated with symptoms such as gastrointestinal upset, migraine, irritation of the nasal mucosa, pruritus and other forms of allergy. In addition, histamine, also known as a proinflammatory agent, is a risk factor for subjects suffering from inflammatory bowel diseases and colon cancer.
Administration of diamine oxidase (DAO) has been proposed to treat certain gastrointestinal dysfunctions induced by histamine, an immunomodulatory, signaling, and proinflammatory factor. However, the H2O2 resulting from the oxidative deamination of histamine by DAO can be toxic. The purpose of this study was to investigate to what extent DAO from snow pea (Lathyrus sativus), alone or in combination with catalase, can modulate histamine toxicity in the Caco-2 human intestinal cell line. The results show that histamine at concentrations greater than 1 mM is toxic to Caco-2 cells, regardless of the state of cell differentiation, with an LC50 of ?10 mM after a 24-h exposure. Depending on its concentration, DAO increased histamine toxicity to a greater extent in differentiated cells compared to undifferentiated cultures. In the presence of catalase, the DAO-induced increase in histamine toxicity was completely abolished in undifferentiated cells and only partially decreased in differentiated cells, showing differences in the sensitivity of Caco-2 cells to the products resulting from catalase. the degradation of histamine by DAO (H2O2, NH3 or imidazole aldehyde). It appears that treatment of alimentary histaminosis using a combination of plant DAO and catalase would protect against histamine toxicity and prevent H2O2-induced damage that can occur during oxidative deamination of histamine.
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