Cart: 0,00€
Isuu Mastodon
  • Free Shipping for all Order of 36,30€ Spain
Cart: 0,00€

Naturdao Legumactive

Legumactive® is a food supplement made from organically selected legumes. This 100% natural method offers a powerful enzymatic activity of three key components: Plant DAO (Diamino Oxidase), Catalase (CAT) and Phytonutrients.

Naturdao Legumactive Naturdao Legumactive

we read it for you

Legumactive ® is a 100% NATURAL method with legumes of organic selection, it offers a powerful enzymatic activity of VEGETABLE DAO (Diamino Oxidase), Catalase (CAT) and Phytonutrients.

Naturdao's Diamino Oxidase is a PIONEER Plant DAO Enzyme as such in DAO deficiency.

Naturdao's Catalase Enzyme (CAT) comes from the membranes of legumes.

The enzyme Catalase (CAT) provides oxygen favoring the balance for the decomposition of the DAO-Histamine reaction . Recent scientific studies made from human intestinal cells indicate that when histamine is degraded by means of DAO, toxic compounds such as Hydrogen Peroxide, Ammonia and Imidazole Acetaldehyde are released from it, however, with the presence of CAT this does not happen

Food supplement based on Legumactive®, which is a 100% natural method with legumes of organic selection, offers a powerful enzymatic activity of DAO (Diamino Oxidase) and Catalase together with its Phytonutrients. Plant Diamine Oxidase (DAO) is the first and only one to hit the market as such, offering 3,000,000 HDU.

Legumactive contains:

  • Peas (Pisum Sativum)
  • Lentils (Lens Culinaris)


Alimentary histaminosis , associated with pseudoallergic phenomena, can occur with the ingestion of histamine-containing foods , such as red wine, beer, chocolate, sauerkraut, fish, and processed meats. Histaminosis is an enteric dysfunction that frequently affects the population of industrialized countries. This disorder is more common in people with low levels of intestinal histaminase, a copper-containing diamine oxidase capable of catalyzing the oxidative breakdown of histamine to produce H2O2, NH3, and imidazole acetaldehyde. Histamine sensitivity is associated with symptoms such as gastrointestinal upset, migraine, irritation of the nasal mucosa, pruritus and other forms of allergy. In addition, histamine, also known as a proinflammatory agent, is a risk factor for subjects suffering from inflammatory bowel diseases and colon cancer.

Administration of diamine oxidase (DAO) has been proposed to treat certain gastrointestinal dysfunctions induced by histamine, an immunomodulatory, signaling, and proinflammatory factor. However, the H2O2 resulting from the oxidative deamination of histamine by DAO can be toxic. The purpose of this study was to investigate to what extent DAO from snow pea (Lathyrus sativus), alone or in combination with catalase, can modulate histamine toxicity in the Caco-2 human intestinal cell line. The results show that histamine at concentrations greater than 1 mM is toxic to Caco-2 cells, regardless of the state of cell differentiation, with an LC50 of ?10 mM after a 24-h exposure. Depending on its concentration, DAO increased histamine toxicity to a greater extent in differentiated cells compared to undifferentiated cultures. In the presence of catalase, the DAO-induced increase in histamine toxicity was completely abolished in undifferentiated cells and only partially decreased in differentiated cells, showing differences in the sensitivity of Caco-2 cells to the products resulting from catalase. the degradation of histamine by DAO (H2O2, NH3 or imidazole aldehyde). It appears that treatment of alimentary histaminosis using a combination of plant DAO and catalase would protect against histamine toxicity and prevent H2O2-induced damage that can occur during oxidative deamination of histamine.


related products

Reviews de Naturdao Legumactive

Related Manufacturers / Laboratories

Related Categories

By clicking on 'accept all cookies', you accept that cookies are stored on your device to improve site navigation, analyze its use, and collaborate with our marketing studies.
Cookie Settings
Accept all cookies

Privacy Preference Center

When you visit any website, it may collect or store information on your browser, generally through the use of cookies. This information may be about you, your preferences, or your device, and is used primarily to make the site work as expected. The information generally does not directly identify you, but it can provide you with a more personalized web experience. Because we respect your right to privacy, you can choose not to allow us to use certain cookies. Click on each category heading to learn more and change our default settings. However, blocking some types of cookies may affect your experience on the site and the services we can offer.

[Cookies Policy] [More information]

Allow them all

Manage consent preferences

Strictly necessary cookies Always active

These cookies are necessary for the website to function and cannot be disabled in our systems. They are usually configured to respond to actions you take to receive services, such as adjusting your privacy preferences, logging into the site, or filling out forms. You can set your browser to block or alert the presence of these cookies, but some parts of the website will not work. These cookies do not store any personally identifiable information.

Performance Cookies

These cookies allow us to count visits and traffic sources so that we can measure and improve the performance of our site. They help us to know which pages are the most or least popular, and to see how many people visit the site. All the information these cookies collect is aggregated and therefore anonymous. If you do not allow these cookies we will not know when you visited our site, and therefore we will not be able to know when you visited it.

Functionality Cookies

These cookies allow the site to offer better functionality and personalization. They may be set by us or by third parties whose services we have added to our pages. If you do not allow these cookies some of our services will not work properly. It also enables storage related to security, such as authentication functionality, fraud prevention, and other user protection.

Targeted cookies

These cookies may be throughout the website, placed by our advertising partners. These businesses may use them to build a profile of your interests and show you relevant ads on other sites. They do not store personal information directly, but are based on the unique identification of your browser and Internet access device. If you do not allow these cookies, you will have less targeted advertising.

Social network cookies

These cookies are set by a number of social networking services that we have added to the site to allow you to share our content with your friends and networks. They are able to track your browser across other sites and create a profile of your interests. This may modify the content and messages you find on other web pages you visit. If you do not allow these cookies you will not be able to see or use these sharing tools.

Confirm my preferences