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Innovation in Skin Care. Transforming lives - Prospera Biotech

Prospera Biotech, a light of hope for cancer patients, has specialized in skin care after treatments such as chemotherapy and radiotherapy. As a result of their studies, they have created high-quality products that relieve skin side effects, backed by testing in real patients. Discover his outstanding career and enduring commitment to transforming lives.

Innovation in Skin Care. Transforming lives - Prospera Biotech Innovation in Skin Care. Transforming lives - Prospera Biotech

Prospera Biotech was born at the end of 2019 with the aim of developing personalized neurocosmetic products for each type of sensitive skin. But our story does not begin there, for more than 20 years we have dedicated ourselves to the study of the skin from the laboratories of the Miguel Hernández University of Elche.

Antonio Ferrer , after more than 20 years dedicated to the study of the dermal neurosensory system and its relationship with skin sensitivity, created Prospera Biotech with the ambition of developing and marketing dermocosmetic products that relieve the sensory discomfort that sensitive skin presents.

Antonio Ferrer , professor at the UMH and director of the Institute for Research, Development and Innovation in Health Biotechnology of Elche (IDiBE) has been elected as representative of the Spanish Society of Biochemistry and Molecular Biology (SEBBM) in the Federation of European Biochemical Societies ( FEBS).

PROSPERA BIOTECH has focused on the study of the neurosensory system, an important skin component responsible for functions as important as touch, the perception of environmental temperature and the detection of irritating, allergenic or harmful substances.

In adverse situations or exposure to aggressive agents, the neurosensory system generates responses in the form of itching or pain and can interact with other skin components, such as the immune system, to cause irritation and inflammation. Therefore, proper care of the epidermal nerve endings helps to soothe the typical discomfort of sensitive skin.

Despite how important the neurosensory system is, it is the great forgotten part of cosmetics.

In recent years, advances in sensory neurobiology have allowed the creation of specific chemicals that act on the neural areas responsible for uncomfortable sensations. These compounds, which are derived from deep scientific and technological knowledge, form the basis of neurocosmetics. Neurocosmetics is an approach in the field of beauty that seeks to solve skin problems based on a solid scientific basis. Its main objective is to relieve skin discomfort and improve skin well-being.

With the firm belief that this knowledge should be available to all people with sensitive skin, Prospera Biotech was founded, which is focused on the development of neurocosmetics as an innovative solution for the personalized care of sensitive skin. Its objective is to create and put on the market a variety of neurocosmetics designed to meet a wide range of needs of people with sensitive skin, in order to improve their quality of life. Sensitive skin is affected by diseases or therapeutic treatments, such as chemotherapy or radiotherapy.

Prospera Biotech neurocosmetic creams provide innovative solutions to relieve dermal sensory manifestations such as, for example, itching, tingling, dryness, and thermal sensitivity of sensitive skin.

At Prospera biotech they have been transforming all IDiBE - UMH research into neurodermatological products for 3 years that help soothe cutaneous sensory discomfort. IDiBE is the institute that has known how to take advantage of entrepreneurship to value translational science at the service of society.

Their first Nocisens® product is a skin care cream. atopic or atopy skin, free of aggressive ingredients, hypoallergenic and suitable for all types of sensitive skin and atopic skin that helps reduce the typical discomfort of dermal sensitivity.
Thanks to its careful formulation with neurocosmetic ingredients, Nocisens® exerts a triple action on the skin:

- Moisturizes in depth.
- Restores the natural balance of the skin, strengthening the dermal barrier and preventing water loss.
- It exerts a powerful antioxidant action that prevents cellular damage.

The next challenge was to carry out an international trial for the prevention of neuropathy associated with chemotherapy treatment, the main side effect responsible for abandoning cancer treatment. In order to carry out this trial, a financing round was opened through the Capital Cell crowdfunding platform.

At IDiBE - UMH Institute for Research, Development and Innovation in Health Biotechnology of Elche, they actively work to bring knowledge in health biotechnology closer to society and patients. Its research areas range from pathologies such as cancer and diabetes to research in infectious diseases, pain or the development of biosensors and advanced materials. In addition to betting on quality teaching, the internalization of research and the dissemination of science.

One of the IBIDE discoveries is that the antitumor drugs most used in chemotherapy (taxanes and platinum salts) increase the excitability of cutaneous neurosensory endings, causing hypersensitization to thermal and mechanical stimuli that could explain the high palmoplantar sensitivity suffered by patients. treaties.

The neurodermatological products developed by Prospera Biotech seek to restore the balance of this neurosensory system. They use neuromodulatory ingredients, active ingredients that exert their action on the cutaneous neurosensory system, which is the cause of the annoying sensations of itching, stinging or pain.

Oncapsisens®, another product from Prospera biotech, is a neurodermatological cream, intended to strengthen the balance of the skin, helping to calm the typical discomfort of skin undergoing chemotherapy .

80% of the volunteers who participated in the Oncapsisens® efficacy trial reported noticeable relief from the uncomfortable sensations resulting from their chemotherapy treatments. For every Oncapsisens® purchased, a portion of the profits are donated to the Spanish Cancer Association .

To do this, UMH researchers print skin in 3D and unite it with the nervous system to understand molecular mechanisms that cause pathologies:

The team of researchers from the Institute of Research, Development and Innovation in Health Biotechnology of Elche (IDiBE) of the Miguel Hernández University (UMH) has developed a model of innervated human skin using 3D printing to understand mechanisms that cause various pathologies that affect the system. sensory nervous system and whose symptoms manifest on the skin. IDiBE researcher Asia Fernández points out that, until now, skin obtained by bioprinting has been used for the treatment of large burns, but so far it has not been included in the sensory system. What is attempted in this project is to connect the two systems, the skin and the nervous system, in order to help understand the molecular mechanisms responsible for sensory pathologies.

3D leather printer

Source: UMH archive

The professor in the Area of Molecular and Cellular Biology at the UMH Asia Fernández explains that in this project they try to ?unite the nervous-sensory system; that is, connecting and innervating this skin in order to give the skin sensory capacity. "This is a model that could be very useful not only to understand the molecular mechanisms of dermatological pathologies, but also to study the toxicity of certain compounds, drugs, even cosmetics, to see that they do not cause irritation or alter the skin."

From the point of view of skin pathologies such as psoriasis or pruritus, this research will help discover new drugs that may be useful. The IDiBE team at the UMH has proven that these phenomena occur with the intervention of skin sensitization of the peripheral nervous system. Currently, the extraction of skin cells is being carried out through human samples, obtained from surgeries that allow sufficient quantities to be obtained to obtain printed skin. The challenge is to innervate this skin with human sensory neurons obtained through the transdifferentiation of fibroblasts, a cell type present in the skin.

Obtaining skin through 3D printing allows us to reduce the use of animals and also create a system similar to that of humans. According to Asia Fernández, ?the results obtained with this study system would be more easily transferable to the clinic, and it would reduce the high failure rate that we find when we try to extrapolate the results obtained in animals to humans.?

Asia Fernandez Carvajal has explained that one of her scientific objectives is the development of an artificial skin model that incorporates a neurosensory system and that with this model we could not only understand the molecular mechanisms of dermatological pathologies, but also study the toxicity of certain compounds. (such as drugs or cosmetics), to see that they do not cause irritation or alter the skin.
Thanks to this new feature, studies can be carried out (against melanoma or psoriasis, for example) with greater translational capacity (since the model is more similar to real tissue) and research in animals can be reduced.
HMGP is a novel neurocosmetic ingredient arising from the research results of the IDIBE (Institute for Research, Development and Innovation in Health Biotechnology of the UMH) from a natural compound that acts on the skin's sensory receptors. According to Dr. Antonio Ferrer, director of IDIBE, ?Its action restores the balance of epidermal nerve terminals, helping to improve sensory discomfort caused by oncological treatments such as hypersensitivity in hands and feet caused by chemotherapy.?

Oncapsisens®, a neuromodulatory cream that contains HMGP along with other moisturizing agents.

The innovative formula of this neuromodulatory cream emerged at the IDIBE-UMH after more than 20 years of study of the neurosensory system, its receptors and the mechanisms in which they are involved, and the scientific studies that support its mechanism of action have been recently published. in the British Journal of Pharmacology. The importance of these receptors has also been highlighted by the scientific community by awarding the 2021 Nobel Prize in Physiology and Medicine to Drs. David Julius and Ardem Patapoutian for their studies on cutaneous thermoreceptors and mechanoreceptors and their therapeutic implication.

Patients undergoing chemotherapy can develop skin hypersensitivity that can cause abrasive pain, heat, tingling and even very annoying sensations of pricks or electric shocks in the extremities. These people also experience high thermal and mechanical sensitivity in their hands and feet, so any friction or change in temperature causes discomfort.

These unwanted sensations occur in between 40% and 80% of patients (depending on the oncological treatment) and are very annoying, leading to the need to reduce doses or even abandon treatments in up to 40% of cases, without that, until now, they had an alternative to calm them down.

With Oncapsisens®, Prospera Biotech's objective has been to increase the quality of life of patients during their oncological treatment .

Oncapsisens®, being a neurocosmetic product, can be used without a prescription and purchased at . These types of products are also called soft-cosmetics since they use active ingredients that, after performing their function, are metabolized by the skin.

Cancer patients who suffer side effects on the skin as a result of chemotherapy already have a neurocosmetic formula on the market developed by the Spanish biotechnology company Prospera to mitigate this annoying hypersensitivity that even causes them to abandon treatment .

The successful completion of the project of the company that emerged from the Miguel Hernández University of Elche (UMH) has been produced after more than two decades of studying the neurosensory system, its receptors and the mechanisms in which they are involved. Scientific studies that support its mechanism of action have been recently published in the British Journal of Pharmacology .


adult hands taking care of a baby's hands

Prospera Biotech's formula is the result of its neurocosmetic research and is developed to mitigate the hypersensitivity that chemotherapy causes in patients and that can even cause them to abandon treatment.

The importance of the receptors that support the Prospera project has also been highlighted by the scientific community by awarding the 2021 Nobel Prize in Physiology and Medicine to Drs. David Julius and Ardem Patapoutian for their studies on cutaneous thermoreceptors and mechanoreceptors. and its therapeutic implication.

These types of products are also called soft-cosmetics since they use active ingredients that, after performing their function, are metabolized by the skin.

Prospera Biotech has been developing neurocosmetic formulations for the care of skin discomfort , beyond the revolutionary cosmetic product to mitigate the discomfort of oncological treatments.

Among its products based on innovation are Nocisens ® and Nocisens ® Intense for the care of sensitive skin with atopic tendency and Nocisens ® Baby for caring for the diaper area in babies. Nocisens® Oil will be released soon, for all those people who need hydration and skin care throughout the body or in large areas.

The startup already has a portfolio with new products, including formulations for sensitivity in intimate areas such as Vulvisens ® or for excessive sweating, Ecrisens ® always with active ingredients that target the nerve terminals that connect the skin with the neurosensory system. molecular-mechanisms-causing-pathologies/ sensory-discomfort-of-oncol%C3%B3gical-treatments (Year 2020 , Vol. 18 , Number 3 Pages (162-172))

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