Benefits of Nigelone®: With Black Cumin Oil, Zinc and Vitamin D3

Nigelone®: The Power of Black Cumin Seed Oil for your Health and Wellbeing

Introduction

In the world of dietary supplements, Nigelone® stands out as an innovative and beneficial product, made from black cumin seed oil (Nigella sativa). This oil is known for its multiple health properties, and its formulation is complemented with Zinc and Vitamin D3. In this article, we will explore the benefits of Nigelone and how it can improve your well-being.

1. What is black cumin?

Black cumin , also known as Nigella sativa , is a plant with a long history of use in traditional medicine. The seeds of this plant have been used for centuries in various cultures for their therapeutic properties.

Black cumin oil contains several bioactive compounds, the most notable being:

• Thymoquinone : This is the main active component, responsible for many of its medicinal properties, including antioxidant and anti-inflammatory effects.
• Fatty Acids : Includes linoleic, oleic, and palmitic acids, which are beneficial for cardiovascular health.
• Other Compounds : Saponins, flavonoids, and alkaloids, which contribute to its antimicrobial and anti-inflammatory properties.

2. Benefits of Nigelone® capsules, based on black cumin seed oil

Black cumin seed oil is rich in nutrients and bioactive compounds, being thymoquinone ( antioxidant and anti-inflammatory agent) one of the most prominent. This compound, present at 2.5% in Nigelone, offers various health benefits, such as:

• It helps stimulate the immune system and improves thyroid function in cases of autoimmune diseases, such as Hashimoto 's disease.
• Reduces inflammation in arthritis .
• It helps, together with drug therapy, to eradicate Helicobacter pylori .
• It contributes to controlling cardiometabolic risk factors, reducing oxidative stress and inflammation .
• Complements therapies for respiratory diseases .
• Helps reduce inflammatory processes of the prostate .
• Improves sleep quality and helps combat stress, anxiety and neurodegenerative diseases .
• It helps to improve skin diseases .

Black cumin seed oil can also be used as a cosmetic oil, its effects at cosmetic level: Nigelone oil® :

• Control of thickening of the epidermis .
• Anti-inflammatory and
• Pain reduction associated with osteoarthritis , mastalgia and psoriasis .
• Helps with skin repigmentation .

1 Nigella sativa oil reduces LPS-induced microglial inflammation: assessment of M 1/M 2 balance.
HOSSEINI A, et al, (2022) Nigella sativa Oil Reduces LPS-Induced Microglial Inflammation: An Evaluation on M 1/ M 2 Balance. Evidence based Complementary and Alternative Medicine, 2022: 5639226 1-11

2 Black cumin seeds powder significantly improve serum lipids, plasma atherogenic index and modulate anthropometric characteristics in patients with Hashimoto's thyroiditis.
FARHANGI MA, et al, (2018) Powdered black cumin seeds strongly improves serum lipids, atherogenic index of plasma and modulates anthropometric features in patients with Hashimoto's thyroiditis. Lipids in Health and Disease, 17 (1): 59 1-7

3 Effects of Nigella sativa on thyroid function, serum vascular endothelial growth factor (VEGF)-1, Nesfatin-1 and anthropometric characteristics in patients with Hashimoto's thyroiditis: a randomized controlled trial.
FARHANGI MA, et al, (2016) The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) ? 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled trial. BMC Complementary and Alternative Medicine, 16 (1):471 1-9

4 Effects of black cumin seeds powder on oxidative stress markers, intracellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in patients with Hashimoto's thyroiditis.
FARHANGI MA, TAJMIRI S, (2020) The effects of powdered black cumin seeds on markers of oxidative stress, intracellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in patients with Hashimoto's thyroiditis. Clinical Nutrition ESPEN, 37 207-212.

5 Can Nigella sativa oil (NSO) reverse PTU-induced hypothyroidism in rats?
ALAWI AA, et al, (2013) Can Nigella sativa Oil (NSO) Reverse Hypothyroid Status Induced by PTU in Rat? Biochemical and Histological Studies. Life Science J, 10 (2) 802-811

6 Role of bioactive compounds from Nigella sativa in the therapy of rheumatoid arthritis: current reports.
ZIELINSKA M, et al, (2021) The Role of Bioactive Compounds of Nigella sativa in Rheumatoid Arthritis Therapy-Current Reports. Nutrients, 13 (10):3369 1-11

7 Study on the role of Nigella sativa oil in the eradication of H.Pylori infection in symptomatic children.
NOHA SA HAMED ESMAIL, et al, (2019) A Study of the Role of Nigella sativa Oil in the Eradication of H.Pylori Infection in Symptomatic Children. The Medical J Cairo University, 87 (Article 131) 3813-3821

8 Effect of Nigella sativa oil extract on cardiometabolic risk factors in type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial.
HADI S, et al, (2021) Effect of Nigella sativa oil extraction on cardiometabolic risk factors in type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial. Phytotherapy Research, 35 (7) 3747-3755

9 Nigella sativa in the control of type 2 diabetes, cardiovascular diseases and rheumatoid arthritis: molecular aspects.
HADI V, et al, (2021) Nigella sativa in controlling Type 2 diabetes, cardiovascular, and rheumatoid arthritis diseases: Molecular aspects. J Research in Medical Sciences, 26:20 1-14

10 Black cumin seed essential oil, as a powerful analgesic and anti-inflammatory drug.
HAJHASHEMI V, et al, (2004) Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytotherapy Research, 18 (3) 195-199

11 Protective effect of thymoquinone, an antioxidant and anti-inflammatory agent, against renal injury: a review.
RAGHEB A, et al, (2009) The Protective Effect of Thymoquinone, an Anti-oxidant and Antiinflammatory Agent, against Renal Injury: A Review. Saudi J Kidney Diseases and Transplantation, 20 (5) 741-752

12 Inhibitory effects of Nigella sativa seed oil on testosterone-induced benign prostatic hyperplasia in rats.
SADEGHIMANESH A, et al, (2021) Inhibitory effects of Nigella sativa seed oil on the testosterone-induced benign prostatic hyperplasia in rats. Biomedicine (Taipei), 11 (1) 19-25

13 Nigella sativa, a promising source of respiratory drugs.
ISLAM MT, (2017) Nigella sativa, a promising source of respiratory drugs. Geum Newsletter, 8 (2) 16-25

14 From the molecular pathology of COVID 19 to Nigella sativum as a treatment option: scientific evidence of its myth or reality.
ATIF M, et al, (2021) From Molecular Pathology of COVID 19 to Nigella sativum as a Treatment Option: Scientific Based Evidence of Its Myth or Reality. Chinese J Integrative Medicine, 2021 1-8

15 Anticancer discovery of thymoquinone: possible mechanisms.
EL-FAR AH, (2015) Thymoquinone Anticancer Discovery: Possible Mechanisms. Current Drug Discovery Technologies, 12 (2) 1-10

16 Thymoquinone from Nigella sativa seeds promotes the antitumor activity of non-cytotoxic doses of topotecan in human colorectal cancer cells in vitro.
KHALIFE R, et al, (2016) Thymoquinone from Nigella sativa Seeds Promotes the Antitumor Activity of Noncytotoxic Doses of Topotecan in Human Colorectal Cancer Cells in Vitro. Medical Plant, 82 (4) 312-321

17 Effects of thymoquinone on pancreatic cancer: evidence from preclinical studies.
BUTNARIU M, et al, (2022) The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies. Biomedicine & Pharmacotherapy, 153, 113364 1-10

18 Thymoquinone-rich black cumin oil improves sleep quality and relieves anxiety and stress in healthy subjects with sleep disorders: a polysomnography pilot study.
DAS SS, et al, (2022) Thymoquinone-rich black cumin oil improves sleep quality, alleviates anxiety/stress on healthy subjects with sleep disturbances- A pilot polysomnography study. J Herbal Medicine, 32 100507

19 Nigella sativa L. and thymoquinone as neuroprotective antioxidants.
TAVAKKOLI A, HOSSEINZADEH H, (2020) Chapter 21 ? Nigella sativa L. and thymoquinone as neuroprotective antioxidants. In MARTIN CR, PREEDY VR, (Ed) Oxidative Stress and Dietary Antioxidants in Neurological Diseases. 2020 325-341 Academic Press

20 Nigella sativa oil reduces LPS-induced microglial inflammation: assessment of M 1/M 2 balance.
HOSSEINI A, et al, (2022) Nigella sativa Oil Reduces LPS-Induced Microglial Inflammation: An Evaluation on M 1/ M 2 Balance. Evidence based Complementary and Alternative Medicine, 2022:5639226 1-11

21 Nigella sativa ameliorates inflammation and demyelination in experimental Wistar rats induced by autoimmune encephalomyelitis.
NOOR NA, et al, (2015) Nigella sativa ameliorates inflammation and demyelination in the experimental autoimmune encephalomyelitis-induced Wistar rats. International J Clinical Experimental Pathology, 8 (6) 6269-6286

22 Thymoquinone restores learning function in a rat model of Alzheimer's disease.
POORGHOLAM P, et al, (2018) Thymoquinone recovers learning function in a rat model of Alzheimer's disease. Avicenna J Phytomedicine ? AJP, 8 (3) 188-197

23 Dermatological effects of Nigella sativa.
ALJABRE SHM, et al, (2015) Dermatological effects of Nigella sativa. J Dermatology & Dermatologic Surgery, 19 (2) 92-98

24 Therapeutic effects of Nigella sativa on skin diseases: systematic review and meta-analysis of randomized controlled trials. 
ASIRI N, et al, (2022) The Therapeutic Effects of Nigella sativa on Skin Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evidence Based Complementary and Alternative Medicine, 2022: 7993579 1-9

25 Dermatological effects of Nigella sativa: cosmetic and therapeutic approach.
SHAMAMA JAVED, et al, (2021) Chapter 5 ? Dermatological effects of Nigella sativa: A cosmetic and therapeutic approach. In ANDLEEB KHAN, MUNEEB REHMAN, (Ed) Black Seeds (Nigella sativa). Pharmacological and Therapeutic Applications. 119-148 Elsevier

26 Effectiveness of topical use of Nigella sativa in the treatment of vitiligo.
SARAC G, et al, (2019) Effectiveness of Topical Nigella sativa for Vitiligo Treatment.Dermatologic Therapy, 32 (4) 1-7

27 Thymoquinone-loaded lipid vesicles: a promising nanomedicine for psoriasis.
NEGI P, et al, (1919) Thymoquinone-loaded lipid vesicles: a promising nanomedicine for psoriasis. BMC Complementary Medicine and Therapies, 19:334 1-9

28 Comparison of topical use of Nigella sativa oil and diclofenac gel on osteoarthritis pain in older people: a randomized, double-blind clinical trial.
AZIZI F, et al, (2019) Comparison of the effect of topical use of Nigella sativa oil and diclofenac gel on osteoarthritis pain in older people: A randomized, double-blind, clinical trial. J Herbal Medicine, 16: 100259 1-5

29 Effect of topical application of Nigella sativa oil and oral paracetamol on pain in elderly patients with knee osteoarthritis: a crossover clinical trial.
KOOSHKI A, et al, (2016) Effect of Topical Application of Nigella sativa Oil and Oral Acetaminophen on Pain in Elderly with Knee Osteoarthritis: A Crossover Clinical Trial. Electron Physician, 8 (11) 3193-3197