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Stress and Histamine Release: An Important Connection
Stress triggers certain responses in the body, including the release of histamine, a substance that has many functions in our immune system. This happens because stress triggers the release of a hormone called CRH (corticotropin-releasing hormone), which stimulates immune system cells called mast cells.
How Stress Affects the Immune System
It's important to understand that not all stress is the same. Our bodies are designed to handle small doses of stress, such as exercise, temperature changes, or even short periods of fasting. These are normal, temporary responses that do not harm our health.
However, prolonged emotional stress, which is very common in our society today, can throw our system out of balance. This type of stress causes stress-related hormones, such as cortisol, to be released constantly. This not only affects our immune system, but also important processes such as digestion and sleep.
The Natural Cycle of Stress and its Alteration
Normally, our hormones, including those related to stress, follow a circadian pattern. That is, they fluctuate during the day and night, maintaining a balance in our body. But when stress is constant, this cycle is altered.
For example, cortisol production, which should decrease at night, can remain high, disrupting our biological clock. This depletes the resources the body needs to protect itself, increasing the risk of infections, chronic diseases and even certain types of cancer.
Gender Differences and Stress
Some studies suggest that women may be more sensitive to the impact of histamine on the brain due to a higher affinity for histamine H1 receptors (Shin Fukudo, et al., 2022). For this reason, it is especially important for women to seek out effective ways to manage stress, as this can directly influence their overall well-being.
Stress and Digestion: The Role of the DAO Enzyme
Chronic stress also negatively affects the digestive system. One of the main consequences is increased intestinal permeability, which allows more histamine to enter the bloodstream. This can cause symptoms such as inflammation, abdominal pain or discomfort related to excess histamine.
This is where the enzyme DAO (Diamino Oxidase) comes into play. DAO is responsible for breaking down histamine in the gut and preventing it from building up in the body. However, if you have low levels of this enzyme, it can be harder for your body to process histamine, leading to symptoms like migraines, digestive issues, and allergic reactions.
The Key: Intestinal Microbiota and Stress
Maintaining a balance in the intestinal microbiota is essential for the proper functioning of the DAO enzyme. Chronic stress can alter this microbiota, making the breakdown of histamine even more difficult.
Tips to Improve DAO Function and Reduce Stress
Feed your microbiota: Include probiotic-rich foods such as yogurt, kefir or kimchi in your diet.
Avoid foods high in histamine: Such as aged cheeses, red wine and sausages, if you suspect you have a histamine sensitivity.
Find relaxation: Activities such as meditation, moderate exercise and breathing techniques can reduce the impact of stress on your body.
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